Sensitivity Analysis of Hazard Ratios to k_inter

Analyzes how the interaction parameter k_inter affects hazard ratios in different populations (overall, harm subgroup, no-harm subgroup).

Usage

sensitivity_analysis_k_inter(
  k_inter_range = c(-5, 5),
  n_points = 21,
  plot = TRUE,
  ...
)

Arguments

k_inter_range

Numeric vector of length 2 specifying the range of k_inter values to analyze. Default is c(-5, 5).

n_points

Integer number of points to evaluate within the range. Default is 21.

plot

Logical indicating whether to create visualization plots. Default is TRUE.

...

Additional arguments passed to generate_aft_dgm_flex.

Value

A data.frame of class "k_inter_sensitivity" with columns:

k_inter

Numeric k_inter value

hr_harm

Numeric hazard ratio in harm subgroup

hr_no_harm

Numeric hazard ratio in no-harm subgroup

hr_overall

Numeric overall hazard ratio

subgroup_size

Integer size of harm subgroup

Details

This function evaluates the hazard ratios at evenly spaced points across the k_inter range. If plot = TRUE, it creates a 4-panel visualization showing:

1. Harm subgroup HR vs k_inter

2. All HRs (overall, harm, no-harm) vs k_inter

3. Ratio of HRs (harm/no-harm) showing effect modification

4. Table of key values